منابع مشابه
RB pockets the cell cycle
In This Issue In This Issue RB pockets the cell cycle idely used cancer therapies inflict collateral damage on normal dividing cells. But now Lohez et al. (page 67) find a way to distinguish normally cycling cells from cancer cells using actin inhibitors that cause an RB-dependent cell cycle arrest. High levels of actin inhibitors prevent cell cleavage and thus lead to a doubling of cellular DN...
متن کاملLoss of Rb launches cell cycle
The elusive cell cycle– transcription link cientists have known for years that transcription is repressed as cells enter mitosis, yet the mechanistic bridge between the two processes has eluded detection. Now, Jian Chen, Beat Suter (McGill University, Montreal, Canada), and colleagues find that Xpd, a component of the general transcription factor complex, TFIIH, regulates another member of the ...
متن کاملA cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration.
Precise cell cycle regulation is critical for nervous system development. To assess the role of the cell cycle regulator, retinoblastoma (Rb) protein, in forebrain development, we studied mice with telencephalon-specific Rb deletions. We examined the role of Rb in neuronal specification and migration of diverse neuronal populations. Although layer specification occurred at the appropriate time ...
متن کاملOf mice without pockets: mouse models to study the function of Rb family proteins.
Three negative regulators of cell cycle, the related proteins, pRB, p107 and p130, constitute the family of pocket proteins. pRB is a tumor suppressor which has drawn a lot of attention on its family of proteins, with the ensuing intense study of their biology. As a result we have a wealth of information on their biochemistry and biology, ranging from their regulation to their biochemical activ...
متن کاملConditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system.
Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb(-/-) embryos also exhibit inappropriate cell cycle activity and apoptosis in the central nervous system (CNS), peripheral nervous system (PNS), and ocular lens. Loss of p53 can prevent the apoptosis in the CNS and lens; however, the specific signals lea...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1611iti1